Oxandrolone (also known under the brands Oxandroline, Anavar, Oxandrin, Vasorome, Anatrofill, etc.) is an anabolic steroid developed by Searle Laboratories. and introduced under the Anavar brand in 1964.
Oxandrolone is a synthetic steroid whose ring A is a heterocycle in which the second carbon atom is replaced with an oxygen atom. Oxandrolone is widely known for its extremely low androgenic activity combined with a high anabolic index.
It has the highest immunostimulating effect among steroids and significantly increases the sensitivity of tissues to insulin. Oxandrolone was originally developed to treat debilitated HIV-infected patients with osteoporosis, osteochondrosis, Turner syndrome, anemia to speed recovery from burns, prolonged bed rest, and obesity-related type II diabetes. Soon it was actively used in bodybuilding, after which Anavar entered the list of controlled drugs.
Effects of oxandrolone
- the main effect of oxandrolone is to increase muscle relief and hardness
- fat burning
- increase in growth hormone levels
- increase in force
navar is not recommended for weight gain. The course of Anavar is recommended for individuals with sufficient muscular tissue mass and average body fat to reduce muscle tension and break down subcutaneous fat.
Oxandrolone for fat burning
Researchers from the University of Southern California conducted an experiment that showed that the removed adipose tissue did not return immediately after this steroid was removed.
The study was supported by the US government and oxandrolone manufacturer, Savient. Men not older than 60 years participated in the 12-week experiment.
The study showed that at 12 weeks, the men not only lost fat, but also gained some muscle mass without exercise. The daily dose of the steroid was 20 milligrams and the adipose tissue loss was 1.8 kg. However, over the next 12 weeks, the muscle mass gained was lost, but the fat burning effect remained. Only 17% of the adipose tissue has returned. It was also noted that greater changes in body composition occurred in the first 6 weeks. For this reason, they tend to take short courses of Oxandrolone as most effective.
The researchers concluded that oxandrolone is a more effective drug for burning fat than for gaining muscle mass. However, let us not forget that the loss of 2 kg of adipose tissue in 12 weeks is achieved without the use of ASA.
The study also showed that burning fat increases insulin sensitivity. This means that the body has been able to cope with less of this hormone in response to the entry of food substrates into the blood, which means that the risk of turning glucose into fat is reduced.
Oxandrolone side effects
Although oxandrolone is an alpha-17 alkylated steroid, its hepatotoxic effects are negligible. Studies have shown that Anavar 20 mg daily for 12 weeks does not affect the amount of liver enzymes (indicators of liver The first signs of liver damage are pain in the right hypochondria, light stools, and dark-colored urine.
Because Anavar is a dihydrotestosterone derivative, it is not flavored (it does not convert to estrogen, which causes side effects such as gynecomastia and fluid retention).
Medium-dose oxandrolone has no significant effect on its own testosterone production (does not inhibit the hypothalamic-pituitary-testicular axis through the feedback mechanism). When the dose of Anavar is high, the body responds by thinking that the levels of endogenous testosterone are too high and reduce the production of gonadotropins. If Leydig cells are not stimulated, testicular atrophy occurs. Oxandrolone at a dose of 80 mg daily reduces testosterone levels by 67% after 12 weeks.
This results in inhibition of testosterone production, decreased libido and sluggish erections. These side effects of oxandrolone can be eliminated by including gonadotropins or in combination with androgenic drugs.
Sometimes Anavar also has side effects such as loss of appetite, abdominal pain, nausea, headache, high blood pressure, and so on.
Overall, oxandrolone side effects are quite rare because Anavar is one of the safest steroids.